Cognitive Functioning and Hippocampal Connectivity in Patients With Longstanding Type 1 Diabetes and Apolipoprotein E ?4

OBJECTIVE While the apolipoprotein E ?4 allele (ApoE-?4) is related to cognitive and brain decline in general population, its effect on type 1 diabetes mellitus (T1DM) remains unclear. Therefore, aim was determine interaction between ApoE-?4 T1DM performance hippocampal structure connectivity as area most vulnerable effects adult patients with T1DM. RESEARCH DESIGN AND METHODS Blood sampling performed 104 49 control subjects for ApoE genotyping, neuropsychology, neuroimaging volume resting-state connectivity. The status presence investigated adjusted age mean systolic blood pressure. RESULTS genotyping could not be three Significant effects, indicating a differential of both groups, were found overall functioning subdomains information processing speed attention. Additionally, present right posterior cingulate supramarginal gyri. Subsequent group analysis showed that worse these domains increased connectivity, relative their counterparts without ApoE-?4. In contrast, no but decreased observed T1DM, higher hippocampus gyrus poorer functioning. CONCLUSIONS results may suggest leaves our more susceptible decrements at younger age, possibly through vascular pathways, warranting further longitudinal studies.